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EMLC is a unique hybrid of liquid chromatography and electrochemistry that combines a three electrode electrochemical cell and a standard HPLC column. In addition to the more conventional separation mechanisms active in liquid chromatography, EMLC uses a potential applied to the column to enhance chromatographic resolution and retention. This controlled column potential introduces another separation mode in the form of electrostatic interactions between solution analytes and the conductive stationary phase. We have used this phenomenon to decrease separation times and manipulate retention order to a degree not attainable by conventional reversed phase separation methods. Another useful feature of this technology is its ability to determine physicochemical properties of analytes in a multiplexed fashion, i.e., the elucidation of thermodynamic parameters, charge interfacial excess, etc.