Professor, Department of Pharmacology and Toxicology
L. S. Skaggs Hall 30 S 2000 E Rm 201 Salt Lake City, UT 84112
Dr. Garold Yost’s research group is interested in the mechanisms of toxicity of nanomaterials, focusing predominantly on respiratory toxicities of environmental exposures by systemic and inhalation exposures, but also on other organ systems. Dr. Yost has several NIH grants focused on respiratory toxicity and lung cancer, with a focus on bioactivation by cytochrome P450 enzymes. His group has significant efforts focused on drug metabolism and P450 enzyme mechanisms of dehydrogenation, which leads to drug/drug interactions, and Dr. Yost would like to apply this research to metabolism of organic components of nanomedicines. Additionally he has an NIEHS-funded grant to evaluate the contribution of TRP ion channels in lung cells to adverse inflammatory responses and acute lung injury of nanoparticles.